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Imagine achieving the remarkable milestone of 100 years – a centenarian, a testament to human longevity and resilience. While genetics undoubtedly play a pivotal role in such exceptional longevity, emerging research and inspiring real-life stories suggest that lifestyle choices, particularly diet, are equally influential. One compelling example of how a whole food vegan diet promotes longevity is evident in the Blue Zones – regions around the world known for having exceptionally high numbers of centenarians and supercentenarians. These populations, including the Okinawans in Japan, the Nicoyans in Costa Rica, and the Sardinians in Italy, exemplify lifestyles centered around diets rich in vegetables, fruits, whole grains, and legumes, with minimal to no consumption of animal-people products. For instance, Okinawans consume a diet low in calories but high in nutrients, including locally grown vegetables like sweet potatoes and bitter melon. The Nicoya Peninsula in Costa Rica has some of the world’s lowest rates of middle-age mortality and one of the highest concentration of centenarians. This is attributed not only to their diet that is heavy on beans, squash, and corn but also to their active lifestyle, strong community ties, and a sense of purpose in life. These factors collectively support physical health, mental well-being, and longevity, providing a compelling model for adopting dietary and lifestyle practices that enhance quality of life into advanced age. Mike Fremont (vegan), who celebrated his 100th birthday in 2022 with a spirited run through his Vero Beach neighborhood in Florida, USA, is a shining example of vitality and resilience. His health journey highlights the benefits of a vegan diet. After being diagnosed with cancer at the age of 69, Mr. Fremont decided to adopt a whole food vegan diet two years before undergoing life-saving surgery. Fortunately, no metastases were found during the procedure. Mr. Fremont believes his dietary change was transformative and crucial to his recovery. Growing scientific evidence supports the preventive effects of such a diet on cancer, and Mr. Fremont’s own experience strongly demonstrates its benefits.